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Abstract Petropoulou SSE, Siskos PA, Tsarbopoulos A:
"Development of chromatography methods for biological monitoring in occupational exposure of carbofuran ",
In ECPROME: 27-30, (Oct 2004)


Keywords    
Abstract   Carbamate pesticides are aryl-ester substituents of carbamic acid. N-monomethyl carbamates known as well as N- methylcarbamates, are the majority of carbamates used especially for their insecticidal activity. The interest on carbamates was renewed in middle ‘50s when the international research focused on substances having a selective anticholinesterase activity combined with less mammalian toxicity, in order to replace some of the very toxic organophosphorus esters being used at the time. Carbofuran is the major representative of the fifteen active compounds of N-methylcarbamates. Carbofuran is the major metabolite of Carbosulfan and a very important active substance on its own. It is used mainly in crops, rice and potatoes agriculture. Its use combines both direct spraying of the plant at the growing stage and direct exposure in form of carbamates’ mixtures on the stored harvest [1]. The purpose of this project was to develop and validate both gas and liquid chromatography methods using mass spectrometric and diode array detection, respectively, for the biological monitoring of exposure to Carbofuran in volunteered farmworkers. This study aimed to fulfill one of the most important gaps in literature in terms of effective and validated methods in biological fluids of a given pesticide formulation and its metabolites. This will assist the evaluation of an individual’s risk assessment in developing health problems from possible exposure to pesticides [2,3].
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Authors:

 3 records found.
Name Affiliation Home page e-mail Total pubs 
Petropoulou SSE   1
Siskos PAEnvironmental analysis group, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Panepistimioupoli, 15771 Zografos, Athens, Greece siskos@chem.uoa.gr8
Tsarbopoulos A   2

Article is cited by:

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References included in article:

 7 records found.
Order of appearence Full citation SRCosmos Link 
1Handbook of Pesticide Toxicology, Second Edition, Vol. 2, Agents, Academic Press, Ch. 52.  
2Harrison PTC, Holmes P, Humfrey CDN,
“Reproductive health in humans and wildlife: are adverse trends associated with environmental chemical exposure?”, The Science of the Total Environment, 205, 97 – 106, 1997.
 
3Stewart AP, Prince KJ, Colt SJ, Ward HM,
“A method for Assessing Occupational pesticide Exposures of Farmworkers”, A.J.I. M., 40, 561 – 570, 2001.
 
4Maurer HH,
“Liquid chromatography – mass spectrometry in forensic and clinical toxicology”, J.of Chrom.B., 713, 3 – 25, 1998.
 
5Bolognesi C,
“Review: Genotoxicity of pesticides: a review of human biomonitoring studies”, Mutation Research, 543, 251 – 272, 2003
 
6Aprea C, Colosio C, Mammone T, Minoia C, Maroni M,
“Biological monitoring of pesticide exposure: a review of analytical methods”, J. Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 769, (2), 191-219, 2002.
 
7Guidance for Industry, Bioanalytical Method Validation”, U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Center for Veterinary Medicine, 2001