|Abstract||Balkan Endemic Nephropathy (BEN) is a chronic tubulointerstitial nephritis whose mosaic like distribution throughout the Balkans has not changed significantly since its initial description in 1950. Hypotheses to explain the occurrences of BEN include genetic predisposition; infection with a slow virus; selenium deficiency; and exposure to selected metals (e.g., As), Ochratoxin A, or polycyclic aromatic hydrocarbons. Here we explore the hypothesis that the occurrence of BEN is linked to the inorganic geochemistry of the environment. Preliminary environmental samples (soils and selected foods) were collected from BEN and non-BEN areas in Bulgaria. Samples were digested in nitric acid and the leachates analyzed for 22 elements by hexapole, inductively coupled plasma, mass spectrometry (HEX-ICP-MS). Selected results include: 1) absolute concentrations from both types of locations were not enriched above “background” concentrations; and 2) As concentrations were typically higher in BEN samples than non-BEN soils and Se concentrations lower; Mo and Al also showed patterns of higher concentration in BEN samples; and 4) depending on the sample type other elemental differences were found between BEN and non-BEN locations. Although geochemical differences between BEN and non-BEN areas were evident, not all difference were found to be statistically significant, in part due to small sample sizes. However, the results do indicate that potentially there are differences in the inorganic geochemistry of BEN and non-BEN areas, that HEX-ICP-MS is an exciting tool to measure environmental geochemical fingerprints, and that the occurrence of BEN is most likely a multifactoral phenomenon.|
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|Included Refrences||18 References (List...)|
|Cited by other Articles||1 Citations (List...)|
|Name||Affiliation||Home page||Total pubs|
|Aryeh Stein||Department of International Health, Grace Crum Rollins Building, Emory University||1|
|Ganev VS||Department of Chemistry and Biochemistry, Medical University of Sofia||6|
|Havezov Ivan||Institute for General and Inorganic Chemistry, Bulgarian Academy of Sciences||1|
|Icopini GΑ||Michigan State University, Geological Sciences, now at Montana Bureau of Mines and Geology, Montana Tech University||2|
|Long DT||Department of Geological Science, Michigan State University, East Lansing, Michigan email@example.com||13|
|Spassov Alexander||Department of Waste Management, National Center of Hygiene, Medical Ecology and Nutrition,||1|
|Voice T||Department of Civil and Environmental Engineering, Michigan State University||1|
Article is cited by:
|Pub Type||Full Citation|
|Conference||Long DT, Voice TC, Niagolova ND, Mcelmurry SP, Petropoulos EA, Ganev VS, Havezov I, Chou K: |
"Aqueous geochemistry of groundwater in a region affected by Balkan endemic nephropathy",
In CEST2003: 557-564, (Sep 2003)
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