|Abstract||Background: The present study assessed the temporal trend in serum concentrations of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls (PCBs) among residents of a Russian town where levels of these chemicals are elevated due to prior industrial activity. Methods: Two serum samples were collected from eight adult women (in 2000 and 2009), and analyzed with gas chromatography-high-resolution mass spectrometry. Results: The average total toxic equivalency (TEQ) decreased by 30% (from 36 to 25 pg/g lipid), and the average sum of PCB congeners decreased by 19% (from 291 to 211 ng/g lipid). Total TEQs decreased for seven of the eight women, and the sum of PCBs decreased for six of eight women. During this nine year period, larger decreases in serum TEQs and PCBs were found in women with greater increases in body mass index. Conclusions: This study provides suggestive evidence that average serum concentrations of dioxins, furans, and PCBs are decreasing over time among residents of this town.|
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|Name||Affiliation||Home page||Total pubs|
|Altshul L||Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, I-B26, Boston, MA 02115, USAfirstname.lastname@example.org||5|
|Birnbaum LS||Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA||1|
|Burns JS||Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA||1|
|Emond C||BioSimulation Consulting Inc., Newark, Delaware, USA||1|
|Feshin D||Institute of Ecology and Evolution of Russian Academy of Sciences, Moscow, Russia||1|
|Hauser R||Department of Environmental Health, Harvard School of Public Health, Landmark Center, 3rd Floor East, 401 Park Drive, Boston, MA, 02215, USAemail@example.com||7|
|Humblet O||Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA||1|
|Korrick SA||Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA||1|
|Lee MM||Pediatric Endocrine Division, Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01532, USA||2|
|Revich B||Center for Demography and Human Ecology of Institute for Forecasting, Russian Academy of Sciences, RAS. 47 Nahimowski Avenue, Moscow 117418, Russia||2|
|Sergeyev O||Chapaevsk Medical Association, Lenina Str., 54B, Chapaevsk, Samara reg. 446100, Russia||2|
|Shelepchikov A||Institute of Ecology and Evolution of Russian Academy of Sciences, Moscow, Russia||1|
|Williams PL||Harvard School of Public Health Department of Biostatistics, Boston, MA, USAfirstname.lastname@example.org||3|
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