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Article summary:

Long M, Andersen BS, Lindh CH, Hagmar L, Giwercman A, Manicardi G-C, Bizzaro D, Spano M, Toft G, Pedersen HS, Zvyezday V, Bonde JP, Bonefeld-Jorgensen EC:
"Dioxin-like activities in serum across European and Inuit populations",
Environmental Health 5 () : 1-13 (May 2006)

Keywords
Abstract	Background: Persistent organic pollutants (POPs) such as polychlorinated dibenzo-p-dioxins/furans, polychlorinated biphenyls (PCBs) and organochlorine pesticides can cause a series of adverse effects on e.g. reproduction in animals and humans, many of which involve the aryl hydrocarbon receptor (AhR). The aim of the present study was to compare the integrated serum level of AhR mediated activity among European and Inuit populations, and evaluate whether the activity was associated to the selected POP markers, 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE). Methods: The study included 338 males from Greenland (Inuit's), Sweden, Warsaw (Poland) and Kharkiv (Ukraine). The AhR transactivity of serum extracts alone (AhRag) and competitive AhR activity (AhRcomp) upon co-exposure with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were determined in the lipophilic serum fraction containing the POPs using the AhR mediated luciferase reporter Hepa1.12cR cell assay. Results: The European groups showed higher median level of AhR-TEQ (TCDD toxic equivalents) compared to the Inuit's, whereas higher incidence of Inuits sample further induced AhRcomp activity. Neither AhRag nor AhR-TEQ were correlated to CB-153 or p,p'-DDE for any of the study groups. Multiple regressions showed a significant heterogeneity of association between the CB-153 and the AhRcomp across the study groups, and accordingly a negative association between AhRcomp and CB-153 was found for the Kharkiv group. Conclusion: No consistent correlation between AhR activities and two POP markers was found. Although the difference of AhRag between European and Inuit men could not be explained by CB-153 or p,p'-DDE levels alone, we believe that the variation of AhR serum activity reflects different pattern of POP exposure, genetics and/or life style factors.
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Authors:

Name	Affiliation	Home page	e-mail	Total pubs
Andersen BS	Unit of Cellular and Molecular Toxicology, Department of Environmental and Occupational Medicine, Institute of Public Health, Vennelyst Boulevard 6, Build. 1260, University of Aarhus, DK-8000 Aarhus, Denmark		bsa@mil.au.dk	3
Bizzaro D	Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona, Italy		d.bizzaro@univpm.it	2
Bonde JP	Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, build. 2C, DK – 8000 Aarhus C, Denmark		jpbon@as.aaa.dk	11
Bonefeld-Jorgensen EC	Unit of Environmental Biotechnology, Department of Environmental and Occupational Medicine, Institute of Public Health, Vennelyst Boulevard 6, Build. 260, University of Aarhus, DK-8000 Aarhus, Denmark		ebj@mil.au.dk	8
Giwercman A	Scanian Andrology Centre, Fertility Centre, Malmo University Hospital, SE – 205 02 Malmo, Sweden		aleksander.giwercman@kir.mas.lu.se	5
Hagmar L	Department of Occupational and Environmental Medicine, Lund University Hospital, SE – 22185 Lund, Sweden		lars.hagmar@ymed.lu.se	7
Lindh CH	Department of Occupational and Environmental Medicine, University Hospital, SE-22185 Lund, Sweden		Christian.Lindh@med.lu.se	3
Long M	Unit of Cellular & Molecular Toxicology, Department of Environmental and Occupational Medicine, Institute of Public Health, University of Aarhus, Vennelyst Boulevard 6, DK-8000 Aarhus C, Denmark		ml@mil.au.dk	3
Manicardi G-C	Laboratory of Genetics, Department of Agricultural Sciences, University of Modena and Reggio Emilia, Viale Kennedy 17, I-42100 Reggio Emilia, Italy		manicardi.giancarlo@unimo.it	3
Pedersen HS	The Primary Health Care Clinic, P.O. Box 1001, DK-3900 Nuuk, Greenland		hsp@gh.gl	5
Spano M	Section of Toxicology and Biomedical Sciences, ENEA Casaccia, Via Anguillarese 301, I – 00060 Rome, Italy		spanomtc@mail.casaccia.enea.it	6
Toft G	Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, build. 2C, DK – 8000 Aarhus C, Denmark		gutof@as.aaa.dk	9
Zvyezday V	Problem Laboratory of Human Reproduction, Kharkiv State Medical University, Klochkovskaya Street 156-A, r. 14, 61145 Kharkiv, Ukraine		dimusic@ic.kharkov.ua	3

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