|Abstract||Background: The study is part of a collaborative project (Inuendo), aiming to assess the impact of dietary persistent organochlorine pollutants (POPs) on human fertility. The aims with the present study are to analyze inter-population variations in serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE), to assess inter-population variations in biomarker correlations, and to evaluate the relative impact of different determinants for the inter-individual variations in POP-biomarkers. Method: In study populations of 3161 adults, comprising Greenlandic Inuits, Swedish fishermen and their wives, and inhabitants from Warsaw, Poland and Kharkiv, Ukraine, serum concentrations of CB-153 and p,p'-DDE, were analysed by gas chromatography-mass spectrometry. Results: The median serum concentrations of CB-153 were for male and female Inuits 200 and 110, for Swedish fishermen 190 and their wives 84, for Kharkiv men and women 44 and 27, and for Warsaw men and women 17 and 11 ng/g lipids, respectively. The median serum concentrations of p,p'-DDE were for Kharkiv men and women 930 and 650, for male and female Inuits 560 and 300, for Warsaw men and women 530 and 380, and for Swedish fishermen 240 and their wives 140 ng/g lipids, respectively. The correlation coefficients between CB-153 and p,p'-DDE varied between 0.19 and 0.92, with the highest correlation among Inuits and the lowest among men from Warsaw. Men had averagely higher serum concentrations of CB-153 and p,p'-DDE, and there were positive associations between age and the POP-biomarkers, whereas the associations with BMI and smoking were inconsistent. Dietary seafood was of importance only in the Inuit and Swedish populations. Conclusion: CB-153 concentrations were much higher in Inuits and Swedish fishermen's populations than in the populations from Eastern Europe, whereas the pattern was different for p,p'-DDE showing highest concentrations in the Kharkiv population. The correlations between the POP-biomarkers varied considerably between the populations, underlining that exposure sources differ and that the choice of representative biomarkers of overall POP exposure has to be based on an analysis of the specific exposure situation for each population. Age and gender were consistent determinants of serum POPs; seafood was of importance only in the Inuit and Swedish populations.|
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|Name||Affiliation||Home page||Total pubs|
|Bizzaro D||Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona, Italyfirstname.lastname@example.org||2|
|Bonde JP||Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, build. 2C, DK – 8000 Aarhus C, Denmarkemail@example.com||11|
|Bonefeld-Jorgensen EC||Unit of Environmental Biotechnology, Department of Environmental and Occupational Medicine, Institute of Public Health, Vennelyst Boulevard 6, Build. 260, University of Aarhus, DK-8000 Aarhus, Denmarkfirstname.lastname@example.org||8|
|Giwercman A||Scanian Andrology Centre, Fertility Centre, Malmo University Hospital, SE – 205 02 Malmo, Swedenemail@example.com||5|
|Goralczyk K||Department of Environmental Toxicology, National Institute of Hygiene, Warsaw, Chocimska 24, P-00-791 Warsaw, Poland||2|
|Hagmar L||Department of Occupational and Environmental Medicine, Lund University Hospital, SE – 22185 Lund, Swedenfirstname.lastname@example.org||7|
|Inuendo||Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, build. 2C, DK – 8000 Aarhus C, Denmark||2|
|Jonsson BAG||Department of Occupational and Environmental Medicine, Lund University Hospital, SE-221 85 Lund, Sweden||Bo_A.Jonsson@med.lu.se||3|
|Lindh C||Department of Occupational and Environmental Medicine, Lund University Hospital, SE-221 85 Lund, Sweden||1|
|Ludwicki JK||Department of Environmental Toxicology, National Institute of Hygiene, Chocimska 24, PL – 00-791 Warsaw, Poland||4|
|Manicardi GC||Laboratory di Genetica, Dip. di Science Agrarie, University of Modena and Reggio Emilia, Viale Kennedy 17, I – 42100 Reggio Emilia, Italy||2|
|Pedersen HS||The Primary Health Care Clinic, P.O. Box 1001, DK-3900 Nuuk, Greenlandemail@example.com||5|
|Rignell-Hydbom A||Department of Occupational and Environmental Medicine, Lund University Hospital, SE – 22185 Lund, Sweden||Anna.Rignell-Hydbom@med.lu.se||5|
|Rylander L||Department of Occupational and Environmental Medicine, Lund University Hospital, SE-221 85 Lund, Sweden||4|
|Spano M||Section of Toxicology and Biomedical Sciences, ENEA Casaccia, Via Anguillarese 301, I – 00060 Rome, Italyfirstname.lastname@example.org||6|
|Toft G||Department of Occupational Medicine, Aarhus University Hospital, Noerrebrogade 44, build. 2C, DK – 8000 Aarhus C, Denmarkemail@example.com||9|
|Zvyezday V||Problem Laboratory of Human Reproduction, Kharkiv State Medical University, Klochkovskaya Street 156-A, r. 14, 61145 Kharkiv, Ukrainefirstname.lastname@example.org||3|
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